"If we score early, Roma don't have anything to lose and they'll open up the game to try and score. That will be a better spectacle if the two teams play an open game and we know that when the game turns open it's always easier for us to get a good result."
Just as Sir Alex Ferguson, Wayne Rooney and countless other squad members have stated in the run-up to Tuesday's game, Queiroz is aware that there will be no repeat of last April's 7-1 mauling of the Italians.
"Roma are a better team this time around," he said. "There has been a lot of progress - they're more consistent and I think the players know each other much better.
"Both sides have a few injuries. It's always difficult to predict football and we don't know what will happen. They have added a few new elements and those players also have great motivation and desire to prove themselves, so it won't be easy."