Manchester United boss Sir Alex Ferguson admits they'll miss Michael Carrick and Owen Hargreaves for their clash with Dynamo Kiev.
"We may go with three players in the middle, as we did in Lisbon. That is certainly a possibility. Whatever we do, the intention will be to try and win the match because the rewards are great for us.
"It's an important game for Kyiv. They will be wanting to win the match and I expect them to have a go. We see it as an opportunity for us because Roma and Sporting Lisbon have a double header against each other.
"From our point of view you would hope they take points off each other. If we can win our games against Dynamo Kyiv then it puts us in a strong position [to win the group].
"The best thing to do is to try and approach the game trying to win it. And that is exactly what we will be doing."