The United midfielder is expected to start at Anfield.
Cleverley told manutd.com: "Yeah, it's fair to say this would be the biggest game I've played in for United if I'm involved. But it's not just a big game for me, it's a big game for the club and of course there's a lot of focus on this particular match.
"Liverpool haven't started so well so I'm sure this will be like a cup final. Meanwhile, we've won our last three games so we're hoping to build on that. It's important we maintain that momentum. It's a massive game for the team."