Isco is unsettled at Real Madrid after being snubbed for Saturday's El Clasico.
The midfielder was overlooked by Real coach Rafa Benitez for the drubbing by Barcelona - a decision that shocked his teammates.
Marca says Isco's dismissal for his foul on Neymar came from frustration at missing out on a starting place.
It's suggested Isco will now seek a move away, convinced he is not valued at Real.
The midfielder is not in the top ten best paid players at Real and his demotion over the past fortnight has further left his camp exasperated.
Arsenal, Manchester United, Chelsea, Liverpool and Manchester City have all made contact with Isco's management to register their interest and to be kept up-to-speed on developments.