Man Utd lose Hargreaves
The injury-plagued England midfielder damaged ribs in training and is unlikely to be risked against the Magpies.
Hargreaves has started just ten games following his £17million arrival from Bayern Munich in the summer.
"Owen got a knock in training in the ribs and is doubtful for Saturday," United boss Sir Alex Ferguson told the club's official website.
"The number of training injuries we've had is amazing."