Sky Sports pundit Neville won eight titles in his 19-year United career before retiring in 2011.
He insisted: "You wouldn't want to fall too far behind a Mourinho team because they would have the nerve to withstand the pressure.
"When he first came in, in 2004-05, we played against him on the first day.
"We'd had the experience the year before when he'd charged down the touchline and gone on to pick up the European Cup with Porto. He'd already made a name for himself. But that first season, he had an absolutely brilliant team at Chelsea.
"Make no mistake about that - Robben, Duff, Drogba, Essien, Makelele, Lampard, Gallas, Carvalho, Terry, Ferreira... "