Neville claimed the winger did not deserve the red card shown him by Turkish referee Cuneyt Cakir for a foot-up challenge on Alvaro Arbeloa in the Red Devils' 2-1 loss to Real Madrid, which sealed a 3-2 aggregate defeat.
He Tweeted: "Been going to OT since age of 5 and I've never seen the whole ground as in disbelief as they were last night at a decision!
"Nani is a player who regularly tries to control a pass like this over his shoulder and its never a red card! Changed the whole game! Poor ref.
"The crowd actually weren't angry / weren't shouting they were just open mouthed and in shock!"