Speaking at the launch of his Sustainability in Sport project, the former United defender is adamant his old club will bounce back.
"When you don't win the championship at United that is always treated as a mini disaster - and I am talking internally, not externally," said Neville.
"The players and manager will be devastated. That is not exclusive to last year, it is every year we never won one.
"But when you think about it, last season was a great achievement.
"The main go-to players, (Nemanja) Vidic and Fletcher, weren't there almost all year, yet it still went down to virtually the final kick of the ball.
"The club will always have to respond to critics and negativity when they don't win trophies. That is the reality of being a Manchester United manager, player or fan.
"You just have to accept it, get on with it and respond.
"I am sure they will. They always have before. There is nothing to suggest this time is any different."