Manchester United goalkeeper David De Gea believes it is an advantage Real Madrid will be missing Iker Casillas tonight.

De Gea admitted it's a significant piece of team news when asked about it at United's pre-match press conference.

"Every time Iker Casillas is not there, he is a great loss," said De Gea, a former servant of Real's local rivals Atletico Madrid.

"It is a great loss because he is the captain of Real Madrid and Spain. But Real have two other keepers who can play as well as Casillas does."