The Mexico international is impressing in his first European campaign.
"We play in the same league and it is going to be tough," said Hernandez, who scored both goals against Marseille on Tuesday to sweep United into the quarter-finals.
"Stamford Bridge is a nice stadium and it makes it a little bit like a league game.
"But if there is an advantage that we are at home in the second game."
Hernandez has scored three Champions League goals in an overall tally of 16 in an outstanding debut season for the Red Devils and he admits the style of the tournament suits him.
"It probably does," he agreed.
"I am trying to think game by game and not to look too far in the future.
"But I am very happy with the way things are going in the Champions League and I want to keep it like that."