Manchester United could lose four senior midfielders in the summer.
The Manchester Evening News says Nani and Anderson face uncertain futures at Old Trafford. Both players are expected to be sold at the end of the season.
Paul Scholes and Darren Fletcher's futures are also up in the air.
Scholes is now back in training after a two-month fight with a knee problem and whether the 38-year-old will sign a new 12-month deal like Ryan Giggs is still uncertain.
Fletcher is still battling his chronic bowel illness following his December operation to help the condition.
The popular Scot's target is next season but whether he can come back to play a key role in the United midfield again has to be seen.