Manchester United boss Louis van Gaal bemoaned his injury woes after victory at Watford.
United's injury crisis has deepened after Phil Jones and Ander Herrera were both forced off during the Red Devils' 2-1 win over Watford.
"We are in a lousy period because there are a lot of injuries," Van Gaal said.
"Jones and Herrera are not available for Wednesday. The first impression is they are not heavy injuries but we have to play Wednesday.
"Jones has a twisted ankle and Herrera maybe a hamstring injury. Rooney is ill and illness is a matter of days, not weeks.
"I do expect that he shall play Wednesday. He is at home. Tomorrow he comes and then I can say more.
"Martial has a foot problem. It is not so heavy as the media has written but you never know, we have to wait and see."