Both players will be missing for Wales against Van Gaal's Holland tonight.
"I am a little bit disappointed but I can understand it because Bale has a difficult, but also impressive, season under his belt," Van Gaal said.
"It is better that we have the best team of Wales because we need resistance. I think Wales without these players are weaker.
"But I have seen Wales play, against Iceland and Finland, and I like the way that they play - they want the ball.
"So it's not a bad team - but with Bale it is always better, with Ramsey also."
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