Wayne Rooney's penalties secured a 2-0 victory in Bucharest and, with home advantage, United will be looking to move on to eight points and close on a place in the knockout stages.
"I don't think there will be a lot of changes," revealed the boss. "Maybe two or three but no more.
"We have to win on Wednesday, without doubt. We're at home and I expect us to win and, if we do that, it's in our hands when we play Benfica at home.
"I expect Benfica to beat Basel as they're in a bit of disarray with Thorsten Fink going to Hamburg. We'll hopefully win our game and, when we play Benfica at home, it'll be the decider in our section."