Manchester United boss Sir Alex Ferguson will draft in Wes Brown for Sunday's clash with Liverpool.
Nemanja Vidic will miss the blockbuster after being sent off in defeat at Chelsea last night.
"I don't think Rio (Ferdinand) will be fit for Liverpool," said Ferguson. "Wes Brown will take over.
"It was a great performance by us. We didn't deserve that. Even in the second half we made some great chances.
"Their first goal was a slack bit of defending at the back post and he took it well. I didn't fear anything, though. I thought we had every chance."
Click here for the No1 coverage of all the gossip and transfer news around Manchester United.