The Mirror says defenders Rio Ferdinand and Patrice Evra, whom Ferguson accused of failing to use their experience to keep the scoreline respectable against City, are set to be his most high-profile victims.
Fergie is said to be ready to pair Nemanja Vidic and Phil Jones in central defence at Goodison, with Chris Smalling and Fabio Da Silva occupying the full-back roles.
In central midfield, Darren Fletcher and Anderson, who were over-run against City, are set to make way for Tom Cleverley and Michael Carrick, with Ferguson determined to send out a clear message to his under-performing players.
Dimitar Berbatov and Michael Owen pushed their claims for starting places with their exploits in Tuesday's 3-0 Carling Cup win at Aldershot, in which both men scored.
But Ferguson has no desire to change his attack, so Wayne Rooney is set to lead the line against his former club with support from Javier Hernandez or Danny Welbeck, as United seek their first Premier League win at Goodison since September 2007.