He wants to emulate former United boss Sir Matt Busby, who led the club to their first European Cup win at Wembley in 1968, 10 years after the Munich air disaster claimed the lives of eight United players and 23 people in all.
A keen believer in fate, Fergie masterminded United's dramatic Champions League Final triumph over Bayern Munich in Barcelona in 1999, clinching an unprecedented Treble on what would have been Sir Matt's 90th birthday.
Then, in Moscow in 2008, when United beat Chelsea on penalties in the first all-English Champions League Final, it poured with rain, just as it did when Fergie won the European Cup-Winners' Cup in Rotterdam in 1991 with United and in Gothenburg in 1983 with Aberdeen.
United take on Marseille tonight in the first leg of their Champions League last 16 tie, with Fergie admitting the prospect of lifting the famous trophy at Wembley in May, just as Sir Matt did, is an inescapable source of motivation.
"Well, it's always an incentive for a final," said Fergie. "The fact that it's at Wembley, which is our own patch, would be nice and special.
"The great memory of Sir Matt winning the trophy after rebuilding the team 10 years on from Munich was an incredible achievement, a very emotional time, also.
"So if we get there, that'll be in my thoughts. I've gone on repeatedly about it, but our biggest challenge is to get a more respectable number of European Cup wins."