Rooney has been out since the draw at Swansea before Christmas while Nani's last appearance was 15 games ago in Braga. Sir Alex also hinted that Javier Hernandez and Antonio Valencia appear primed to complete the front-four positions.
"Both [Rooney and Nani] will play," confirmed the boss to MUTV. "Both are fit.
"[There's] Chicha and Antonio, we've got a strong squad, you know. There won't be many changes really. Wayne coming back is good news. He's been training for a week and looking good. As for Nani, he came back from his spell abroad [having a break in Dubai] and is really looking very good. So I'm fine and will play a strong team."