Roma are back at Old Trafford in the Champions League - the scene of their 7-1 humiliation against Ferguson's goal-greedy troops in last season's quarter-finals.
And the United manager has warned that Roma will be out for revenge.
"They will want to win this one more than ever. "It will be a big, big motivation for them. We will have to keep cool and just play our game. If we win we will be on six points and will be in a marvellous position.
"Roma won't want a repeat of what happened last season. It was very difficult for them to get over it.
"They had to endure all sorts of taunts. They had a derby match against Lazio two weeks later and there was a lot of stick flying in their direction. I would settle now for a 1-0 win."
Ferguson admits the performance against the Italians, who lead Serie A this time around, was the most complete exhibition of controlled football in his Old Trafford tenure.
"It was the most emphatic in Europe in my time at the club," he said. "I have always been searching for perfection and we've got near to that a few times. Roma last season was one of those games.
"In terms of our movement and penetration, even if it had been 3-1 or 4-1 it would still have been almost perfection."