United went into the return leg at home to Bayern Munich trailing 2-1, but stormed into a three-goal lead.
But it all went pear-shaped when Rafael da Silva was sent off and Munich hit back twice to make it 4-4 on aggregate and go through on away goals.
Fergie says the pain of going out 12 months ago still hurts and is determined to avoid a repeat.
He said: "We played some fantastic football that night and did not deserve it.
"But you need a bit of luck in a game like that and hopefully we'll get that this time.
"We were 3-0 up and it could have been four or five, but they got a goal right on half-time, so the mood of the dressing room is different because of that.
"They knew then that one more goal would put them through and then we had young Rafa sent off, which was really a harsh decision, I felt.
"But the game swung their way in terms of, like what German teams can do, their patience and control of the game in terms of possession.
"It looked as if we were just going to hang on, but (Arjen) Robben hit that absolutely fantastic goal, so concentration is vital because goals change games.
"We are all aware of that and I hope the goals come from us."