Ferguson said: "Experience is important and that's why my team might be different in Lisbon. Benfica-United has a ring to it because of the history. But it's an important game in its own right. Whoever wins gets a valuable headstart in the group.
"There's no doubt the younger players will get good experience in the Champions League this season, but the important thing is to qualify.
"The home games will be better for them. Our first home tie is against Basel and the young players are capable of playing in that kind of match.
"But Benfica away is one you have to respect. They will be a handful. We always expect a difficult game there. They operate with three midfield players and we will have to look at that, as it will be the hardest part for us."