Ferguson was happy at the way Van Persie and Kagawa combined in a thrilling first-half display.
"It was fine," he said.
"Obviously it is early doors and there will be a better understanding as time goes on."
And it seems Ferguson is intent on operating with someone occupying a deeper role behind Van Persie, suggesting Rooney will not be able to take his first-team place for granted.
"We normally do that, whether it is Wayne who plays in that role, or Danny Welbeck can do it," said Ferguson.
"Ashley Young and Ryan Giggs can play there. We have options that way."