The likes of Gerard Pique, Danny Simpson and Jonny Evans are all set to be handed a starting berth against Roma on Wednesday night. And despite suffering an embarrassing Carling Cup against Coventry City back in September, Sir Alex is confident they won't let him down this time round.
"We don't want to send teams out here to get humiliated or embarrassed, that's for sure," he insisted at his pre-match briefing in the Italian capital.
"We expect any Manchester United team we field to be 100 per cent committed and I'm sure you'll see that on Wednesday night."
The Reds will be up against a Roma side whom Sir Alex believes are a much stronger outfit that last season. He was also full of praise for the way the club have stood by manager Luciano Spalletti following their humiliating 7-1 defeat at Old Trafford in April.
"When a coach in Italy loses a game 7-1, normally the guns come out and you are dead before morning," declared the United boss.
"But they trusted Luciano and stood by him. He has repaid that trust because he is an excellent coach and I am very pleased his team is doing well now."