United could be handed Barca in tonight's Champions League quarterfinals draw.
"It is not good tactics to go into how good Barcelona are and show trepidation or apprehension about it," said Ferguson.
"I don't think that is our way.
"You have to face every hurdle as it comes along.
"We have the experience of playing Barcelona recently. We knocked them out in the semi-final and then lost the final to them in Rome the following year."
Ferguson feels the less physically demanding football of Spain helps Barca.
"The amazing thing about Barcelona is that they very rarely change their team," said Ferguson.
"It is a fantastic feat when you consider all the games you play nowadays.
"I don't know what they do in their training. Maybe they carry luck with injuries?
"Spain is a different type of football. That may be a help. The climate is better. That may be another reason.
"But we have a big squad because the game in this country drains you. You couldn't play the same players every week. Not in our country."