Ferguson feels Roo and RVP can be as fearsome for United as Dwight Yorke and Andy Cole were 13 years ago.
The Old Trafford chief said: "Van Persie is flexible because he can play in different positions.
"He is such a mobile player, there are great options with him. And Wayne can play behind and he can play up.
"Hernandez is the only one-position player and that is through the middle.
"Can Wayne and Robin play together? Yes, absolutely - no doubt about that.
"And Welbeck can play with them, there is no question about that."