As one of the players not being troubled by international duty, Rio Ferdinand can expect significant involvement following his controversial trip to Qatar, whilst Ryan Giggs, Nemanja Vidic and Anderson should also be fresh.
"Every coach is praying that their players come back fit," said Ferguson.
"They played last Friday and they are playing tonight. Once I know later this evening how many minutes each player has played, I will start to think about my team for Saturday.
"I have to make sure I have some freshness in the team because we also have Chelsea on Monday lunchtime.
"It is a big ask for our squad and something we need to concentrate on because I need to make sure I pick the right teams."