The Ecuador winger was injured at the Copa America in the summer but has been working hard to get back to full fitness and has been rewarded with a place in the party for the Reebok Stadium visit.
Javier Hernandez is in good shape after his exertions with Mexico and is in contention for his first start of the new season but Sir Alex does not expect to make too many changes to a winning side.
"There's no new problems after the internationals," said the boss. "Hernandez is fit. He played two lots of 45 minutes for Mexico and scored a goal. It's terrific for him to have the two halves, he's ready and has trained very well.
"The only concern was the rest time he needed after the concussion in the US. Otherwise he was fine.
"Valencia's doing very, very well - he's in the squad for tomorrow.
"Rio Ferdinand's available but none of the back four deserve to be dropped so I don't anticipate many changes in the team."