United face Besiktas at Old Trafford on Wednesday night at the top of Group B.
And Ferguson will utilise his squad in the belief that staying at the summit is not as important as previous years.
He added: “I will freshen the team up because finishing first or second doesn’t seem to be as important this year. We want to keep our consistency in the competition. We have got a good record, both at home and away, and we want to maintain them both.
“Look at the group with Rubin Kazan, Inter Milan and Barcelona. Now that’s an interesting one and I really can’t pick a winner there. If it’s Lyon or Fiorentina, who would it be best to face? There’s not a lot between them.