Giggs, 34, was rested for the FA Cup victory against Arsenal at the weekend so he would be in the best possible shape to face Lyon in the first leg of the knockout phase on Wednesday.
The Welsh star's career at the top level of European club competition has spanned 15 years and shows no sign of slowing down.
Ferguson said: "There are only a few players who have reached that milestone.
"That is because of Ryan's ability, his longevity and how he prepares - you just have to look at his lifestyle.
"He is obviously at a successful club as well and for me he has been an absolute model in his time with us. Even at 34 we expect big things from him.
"We do not play him in every game but that is natural for someone of his age - but he will play tomorrow (Wednesday).
"It will be a great occasion for Ryan and we are all proud of him."