United fell 1-0 to Burak Yilmaz's second-half header.
"It is a fantastic stadium and obviously an improvement from the old one," said Ferguson.
"There is not much difference in the atmosphere.
"The biggest change since then is that we have won the competition twice and we have qualified for the last 16 this year too."
Galatasaray will join them if they match Cluj's result at Old Trafford in a fortnight.
"We'll play a similar team against Cluj, that goes without saying," said Ferguson.
"We've qualified and there's no reason why we shouldn't use the squad."