Robin van Persie, Wayne Rooney and Shinji Kagawa are all fit to start for United at White Hart Lane but Danny Welbeck's man-of-the-match performance against Liverpool last weekend means Ferguson is loathe to drop the England youngster.
Ferguson said: "You want to be able to say to someone 'I'm leaving you out not because you did not play well last week - you played great - but I'm going to pick a different team'.
"It's difficult to leave players out. You have to speak to them. The days of just putting a team up on the notice board are gone. The stats of players' running performance over the last 10 years have soared. It's amazing. As the game gets quicker and more energy gets spent you have to think more about picking your teams. Players do accept being left out now. I'm not saying they enjoy it but they handle it not too badly."