United are going to have to play more matches than title rivals Manchester City who have no European football to distract them in the New Year.
Fergie said: "They haven't got travel and recovery from the game in midweek in Europe to worry about.
"But hopefully the size of squad and experience we have got with European football we can do that.
"The second half usually decides it anyway so you have to manage playing European football and playing league games.
"We have been doing that for quite some time and I don't think that's a problem."