The Red Devils take on the Bundesliga side at the BayArena on Matchday 5 but will have to navigate the trickly away trip without their star striker and key defender.
United boss David Moyes said: "They are both injured. Neither of them are long-term but they are not quite ready yet."
van Persie will miss with a groin injury while Vidic is unavailable because of a concussion.
For breaking stories and all the great banter like us on Facebook: facebook.com/tribalfootball