Rooney has his sights on becoming one of England's top five goalscorers.
He is currently on 29 and two more against the side ranked 207th in the FIFA world rankings would lift him into fifth spot and above Alan Shearer, Nat Lofthouse and Tom Finney, who have all netted 30 times for England.
Rooney said: "People have mentioned I will get into the top five (goalscorers) if I get a couple more and that would be great.
"Obviously, the result is more important but it's an opportunity for us to try and get a few goals. We have to make sure we don't take them too lightly and we don't relax during the game.
"We have to forget they are ranked 207th, focus on ourselves, try and play the football we've been trying to do.
"We've seen a couple of things (about San Marino) and to be honest there is a great chance for us to win the game and score goals.
"We've seen lower league teams knocking big teams out of cup competitions and we need to stay focused - but we expect ourselves to win."