The Euro 2008 co-hosts provide the opposition for Fabio Capello's first game in charge of England on Wednesday.
Arsenal defender Senderos is expecting a tough test knowing England's players will be out to impress Capello.
"A friendly game does not get any better than this to play at Wembley against England," Senderos told Sky Sports.
"They will definitely be up for it. The fans and the team will want to show they belong to take part in a big tournament like this [Euro 2008].
Manchester City midfielder Fernandes admitted everyone in the Swiss squad was excited at playing at Wembley against England.
"All the players here are very, very excited to play against England in Wembley it is like a dream for us," admitted Fernandes.
"I don't what type of game it could be. A hard game, very passionate game it is the first game for Capello in England and we are excited for that."