Boss Manuel Pellegrini said: "He is a very important player, it is impossible not to miss him.
"In the last two weeks I said this was not an excuse because we have had a lot of injuries during the year.
"In the last two weeks maybe we have had injuries in the same position and that has been a major problem.
"Samir Nasri is a very important player and we always miss him, but with the squad we have I think we can also win without him."
Two other key players in top scorer Aguero and midfielder Fernandinho remain on the sidelines but Javi Garcia is also fit again after a muscle strain.
Pellegrini said: "I think it is very important to have players, Samir Nasri and Javi Garcia, fit for this game. It is very important for us.
"(Matija) Nastasic, Fernandinho and Aguero are not fit for this."
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