The Daily Mail says Bernabeu executives have opened talks with Cavani's advisors over a money-spinning swoop.
The Real delegation are said to have made abundantly clear their intentions to land the player.
The news provides a major obstacle in City's attempts to sign Cavani, who has a £52million release clause written into his contract.
Napoli insist he will not be allowed to leave without a club meeting that release clause.
Should City outbid Real for Cavani? Is he worth his buyout clause? Give us your shout below...