The Spanish striker feels the Catalan giants must be favourites to win Europe's premier club competition but suggests that City can possibly get one over them if they perform at their best in the Round of 16 first leg at the Etihad Stadium on February 18.
"Looking at the history, for the numbers of titles they have, Barcelona is the favourite," Negredo said.
"It is true that now they are not as good as in previous years but Barca are always Barca and you have to be very careful with them. We must have the courage to face them.
"We have a good squad, quality and anything can happen if we do things right."
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