The 24-year-old Argentina striker has been out since injuring his knee in City's opening game of the season.
"We will try this morning with Sergio," Mancini said. "And after we try we will decide. He is getting better."
When asked if he could be involved at the Britannia Stadium on Saturday, the Italian added: "Maybe."
Fellow striker Mario Balotelli has been cleared to play against Stoke if needed after undergoing laser eye surgery during the international break.
The Italian had had difficulty wearing his contact lenses after being affected by conjunctivitis.
Mancini said: "Mario is OK. Mario now sees everything."