The pair were outstanding in City's rout of Champions League opponents CSKA Moscow this week.
"He [Aguero] is benefiting amazingly from the inclusion of Negredo in this team because Negredo is a big, skilful type of old fashioned centre forward," Lee told talkSPORT.
"He's good in the air, he picks the ball up, he uses it well and Sergio is now having a different lease of life. Before he was the lead striker having the ball played into his feet when he's got his back to the defender.
"This guy [Negredo] has taken a lot of the brunt of that and Sergio is receiving the ball going the right way facing the opposition goal."
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