Balotelli was again amongst the goals in victory over Salzburg this week.
"Bolton are improving and have a good manager," Mancini told City's website. "I think they may have surprised a few people. It will be a hard game for us.
"But we are playing well and we are improving. Mario being available is a big help and I think he can play alongside anyone. He did well in midweek as did Adam Johnson and others.
"I have no doubts that Mario can play alongside Carlos Tevez, Emmanuel Adebayor, David Silva, Jo and Roque Santa Cruz. They are all experienced players and they can all complement one another. This is important."