He insists Sterling is strong enough to deal with the taunts of rival supporters ahead of Saturday's return to Burnley for the first top flight game of the weekend.
When he last played at Turf Moor, 15 months ago, Manchester City's England star was goaded with chants of, “You've let your country down" over his role in their Euro 2016 failure.
“He's young and I think he's shown amazing things at difficult stages this season, playing at a good level home and away.
“I don't think he's a guy who is scared to take responsibility, I think he showed many, many good things this season in those terms."
Guardiola played down Sterling's disappointing display at Burnley last time.
“No, I don't think too much about that," he said. “Burnley away is a complicated game — and every away game is complicated."