He believes that the way fixtures are allocated during this period of the season "kills the players," and is not sustainable.
Guardiola spoke about the state of affairs after his side's 3-1 win at Watford in the Premier League, which helped City maintain a massive lead over the chasing pack heading into the second half of the season.
"We made five changes from the last game but it's not our fault. I know here in England the show must go on, but that's not normal guys. The big bosses should reflect that," he said.
"We're going to kill the players. The federations don't think about the players but they have to. They play 11 months in a row.
"They have to protect them and play with quality and not quality. We have to think about the artists. But I know it won't happen.
"Watford scored because they have good players. We will review the action but people can not expect us to win 7-0 every time."