The Argentina international spent five years with Atletico Madrid, scoring 74 goals in 175 games, and although some of those strikes came against the Galacticos it was never enough to secure victory.
"It's always special to play against a club like Real Madrid," he said.
"Personally, my connection with Atletico Madrid gives it an additional kick - but there's no difference in how much I want to win this match.
"Never defeating Real when I was with Atletico was a real regret for me - Atletico haven't succeeded in beating them for many years - but I did get to score against them even if we never managed a win.
"Wednesday night will hopefully break that run for me."