The 32-year old left-back, on a season-long loan from Manchester City, has missed the Seagulls' past four Championship matches because of a calf problem but Poyet suggests he could be back in action for the trip to Charlton Athletic on Saturday.
"Marcos Painter suffered a small tear in his calf during the week and we expect him to be out for two to three weeks, but you can never be sure nowadays," said Poyet.
"Wayne Bridge and Adam El-Abd were not ready (for the weekend's loss to Crystal Palace) so I could not play them, then when we needed a little help from Orlandi he had to go off injured. We think he has broken his rib.
"Wayne has the best chance of being ready for Saturday so we need to hope that the medical staff can produce something special this week.
"Unfortunately it's mainly the defenders who are injured and we need people to stand up now. We have a week to go until the next game and we need to relax and be ready."