The Reds host the league leaders at Anfield in the early game on Saturday and despite a 1-1 draw at West Bromwich Albion last week, Skrtel suggests the Merseysiders are in good enough form to cut the Gunners down.
"I am confident we can beat Arsenal because we definitely have the strength to do so," he said.
"They are the leaders at the moment but we can give them a hard time.
"It won't be an easy game but I am sure we can do something in front of our fans."
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