The Reds host City at Anfield on Sunday and even though they were beaten 3-0 by West Bromwich Albion on the road last weekend, Reina is expecting Brendan Rodgers' team to make life difficult for Roberto Mancini's men.
"We don't have the easiest run of fixtures coming up, but they are what they are," Reina told the Liverpool Echo.
"We have to face them and I'm sure for them it won't be easy to come to Anfield.
"We have to make ourselves strong at home. This year we have to get better results at home."
Regarding the loss, he added: "It's not normal [to lose]. But I don't think we will see many games for Liverpool like we did on Saturday.
"There is nothing to worry about. This is just early days. It was a bad game, and it is as simple as that."