Meireles already holds experience of playing at Old Trafford having helped Porto to a 2-2 Champions League draw at the home of Alex Ferguson's side in 2009.
Now the Portuguese star is aiming to make an impact for Liverpool as they attempt to deliver a statement of intent against their arch rivals.
"I have played there before and we did very well," Meireles told liverpoolfc.tv. "We drew 2-2 but I am too young to have played there in the Costinha game which Jose Mourinho won [in 2004].
"But I am not nervous at all at the prospect of going there so early in my Liverpool career. These types of games, really big games, are the best ones to play in.
"Every player dreams of playing in these games and I am the same. That is why I came here, to have the chance to play in games like this."