"This derby means so much to me and the other players," Reina told The Daily Star.
"I have been living in Liverpool for some years now and I understand how the supporters feel. But we need to win not only to beat our rivals, but also to prove that getting to the top was no accident.
"We know that Everton will give 100 per cent and will be highly motivated, especially at home.
"This is a big danger for us because we will need to try and control the situation from the first minute to win.
"The Stoke game was a mistake. The 0-0 was unjust but now our heads are with the Everton game.
"The Premier League still has a long way to go but our mission is to avoid too many failures in the beginning. If we want the title it is impossible to miss points at Anfield.
"On Saturday we will need to forget it is Everton we are playing. If we play at our best we will win."