England manager Fabio Capello has vowed to use the game to experiment but Reina says a strong Spain side will be out to dent England's preparations for Euro 2012.
"For those of us who play our club football in England this is a very special game," Reina said.
"I'm looking forward to it and I hope to play in it but Del Bosque must decide that.
"There is no such thing as a friendly these days. Whenever you go away with your national team you always want to win.
"We are champions of Europe and champions of the world, and we want to keep winning."